August 20, 2021
2018 saw accelerated understanding of the roles of stem cells in health and disease. The Shruti Naik lab at the Rockefeller University Howard Hughes Institute demonstrated close interrelationship between immune cells and stem cells. Stem cells store memories of prior activation by stress through specific epigenetic modifications that activate specific genes within stem cells. (1) Chronic inflammatory diseases such as asthma may be driven by stem cell memories. Interleukins, key molecules controlling immune cells, appear to be drivers of the inflammatory responses since antibodies to cytokines block inflammatory responses. Similar stem cell memories may underlie chronic gastric inflammation such as Crohn’s disease and irritable bowel disease. (2)
Vitro Biopharma supplies DVCStem (www.DVCStem.com) stem cells for an IRB-approved clinical trial of systemic inflammation that includes a large range of diseases such as multiple sclerosis (MS), Alzheimer’s disease (AD), injuries and other conditions. Phase I results show an absence of adverse events and support efficacy. Our trials include measurement of multiple inflammatory cytokine responses to stem cell therapy. Our protocol consists of IV infusion of umbilical cord-derived MSCs produced in our c-GMP-compliant, FDA-registered, ISO9001:2015 Certified, & CLIA-registered lab. Also during 2018, allogeneic MSC therapy was approved by the European equivalent of the FDA (EMA) for treatment of a form of Crohn’s disease.
Additional advances in 2018 support stem cell dysfunction as a cause of disease and foster the concept of stem cell diseases. Osteoarthritis (OA) has been subject of extensive clinical testing in animals and humans. Iijima and colleagues recently reviewed results of clinical testing in 2385 patients in 35 studies. Therapy involves injection of expanded MSCs into the diseased joint. The results support safety and efficacy including pain reduction, recovery of function and regeneration of cartilage (3). Reduction of stem cell function is thus likely an important factor in the development of OA. Anti-aging trials showing reduction in frailty by MSC transplants also implicate stem cell dysfunction in age-related frailty, a major issue in geriatric medicine. Further advances in 2018 showed specific reduction in anti-oxidative responses in MSCs derived from multiple sclerosis (MS) patients suggesting stem cell dysfunction may also be involved in development of MS (4). There is also support for stem cell dysfunction as a causative factor in Alzheimer’s disease (AD). We postulate that stem cell therapy is effective by replacing dysfunctional patient stem cells that cause OA, MS, and age-related conditions such as AD. Vitro Biopharma has ongoing and pending clinical studies of MSC therapy for MS, OA, PD and AD in addition to systemic inflammation.
By Jim Musick, Ph.D. CSO of Vitro Biopharma/Vitro Diagnostics, Inc.; Tiana Tonrey, MS, COO, Vitro Biopharma
August 31, 2021 0 Comments
Golden, Colorado-August 31, 2021- Vitro Biopharma, Inc. ("Vitro') announced the acquisition of Fitore Nutrition ("Fitore") and Infinivive MD ("Infinivive"). Fitore, a private company headquartered in Denver, Colorado creates clinically validated supplements and sells them direct to consumers (D2C) via their unique digital marketing platform and SEO expertise.
Infinivive, located in Cherry Creek, Colorado developed the world's first topical cosmetic stem cell serum and is a nationally recognized company led by one of the top industry pioneers in the area of cosmetic surgery, Dr. Jack Zamora M.D.
August 20, 2021 0 Comments
August 20, 2021 0 Comments
Vitro Biopharma, Inc. announced receipt of FDA authorization and clearance to enroll patients in its phase I-IIa, randomized, double-blinded, placebo controlled study of the safety and efficacy of therapeutic treatment with AlloRx Stem Cells® in adults with COVID-19. Our Investigational New Drug (IND) application will investigate the clinical effects of AlloRx Stem Cells® by studying safety and efficacy in patients with moderate to severe COVID-19.